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KMID : 0903520050480010093
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
2005 Volume.48 No. 1 p.93 ~ p.97
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Structures and Antioxidant Activity of Diketopiperazines Isolated from the Mushroom Sarcodon aspratus
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Kim Jin-Woo
Moon Byung-Sik
Park Young-Min
Yoo Nam-Hee
Ryoo In-Ja
Nguyen Thi Chinh
Yoo Ik-Dong
Kim Jong-Pyung
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Abstract
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Three antioxidants, Sa-1, Sa-2 and Sa-3, were isolated from the MeOH extract of the mushroom Sarcodon aspratus through EtOAc extraction, silica gel and Sephadex LH-20 column chromatography, and C18 HPLC. The structures of the compounds were determined mainly by NMR and mass spectroscopic data analyses. Sa-1, Sa-2 and Sa-3 were identified as diketopiperazines, and their structures were determined to be cyclo(prolyl-valyl), cyclo(prolyl-leucyl) and cyclo(prolyl-isoleucyl), respectively. This is the first time that these compounds were isolated from this mushroom. They showed antioxidant activity by scavenging DPPH radical (EC50 0.15~0.18mM) and superoxide radical (EC50 0.21~0.24mM).
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KEYWORD
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Sarcodon aspratus, diketopiperazine, cyclo(prolyl-valyl), cyclo(prolyl-leucyl), cyclo(prolyl-isoleucyl), antioxidant
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